Query Gene to explore Correlation with EMT Signature (EMTscore) profile

Gene of Interest
Signature Name	Aiello et al.2018-EMT-related genes in pancreatic adenocarcinoma(Pancreatic cancer,PMID29920274) Alsuliman et al.2015-17 EMT signature genes(Breast Cancer,PMID26245467) Andarawewa et al.2007-Gene expression profile EMT signature of IR and TGFbeta treated (Human mammary epithelial cells,PMID17875706) Becker-Santos et al.2012-The EMT transcript signature in human prostatic epithelial cells (PrEC)(Prostate Cancer,PMID23027626) Berardi et al.2015-ATRA treatment modulated EMT signature(Breast cancer,PMID26044847) Budinska et al.2013-EMT/ Stroma Gene Signature Colorectal Samples (n= 1113)(Colorectal cancer,PMID23836465) Byers et al.2013-EMT- Gene Signature Predict Resistance to EGFR and PI3K Inhibitors (Non-small cell lung carcer,PMID23091115) Cao et al.2020-Prognostic EMT‚Äêrelated gene signature in bladder cancer(Bladder cancer,PMID31657881) Castilla et al.2011-MicroRNA signatues associated to EMT in human carcinosarcomas(Endometrial Carcinosarcoma,PMID21125666) Chae et al.2018-Comparison of EMT-related genes and T-cell infiltration in non-small cell lung cancer(Non-small cell lung carcer,PMID29440769) Chen et al.2013 -Heterogeneous expression profiles of EMT-related and other genes among CTCs, Human Patients (n=9)(Prostate Cancer,PMID23280481) Cheng et al.2014-A signature of EM plasticity and stromal activation in primary tumor(Breast Cancer,PMID25060555) Choi et al.2010-A cell line-derived EMT signature(Breast Cancer,PMID20215510) Choi et al.2017-TWIST-induced EMT in HMECs(HMECs cells,PMID29228692) Chung et al.2006-Gene expression signature of EMT genes deregulated in high risk HNSCC(Head and Neck Cancer,PMID16912200) Chung Jin-Haeng et al.2011-EMT in acquired resistance to EGFR-TKIs(Lung Cancer,PMID21168239) Cieslik et al.2013-EMT-Signature from a manual search of recent literature(Non-small cell lung carcer,PMID24004852) Creighton et al.2009-EMT profile in CD44(+)/CD24(-/low)-MS and claudin-low signatures (Breast Cancer,PMID19666588) Cristescu et al.2015-EMT signature in gastric cancer(Gastric cancer,PMID25894828) Cursons et al.2015-EGF- and/or hypoxia-induced EMT (MDA-MB-468, PMC42-ET, PMC42-LA)(Breast cancer,PMID25975820) Deka et al.2010-Transcriptional regulators and functional markers that are involved in EMT(Colon cancer,PMID20682801) Deng et al.2019-WISP1 induced an EMT gene signature (Melanoma,PMID30723155) Doherty et al.2017-Interferon-stimulated genes are downregulated in EMT(Triple Negative Breast cancer,PMID29229854) Du et al.2016-TGFB- and OSM-induced EMT (H358, MCF10A)(Lung/Breast cancer,PMID27318801) Ekanem et al.2019-EMT associated 3-gene signature(Prostate cancer,PMID31060254) Fardin et al.2009-Induction of EMT and vasculogenesis in the lenses of Dbl oncogene transgenic mice(Onco-Dbl transgenic mice,PMID19759912) Foroutan et al.2017-A Transcriptional Program for Detecting TGFbeta-Induced EMT in Cancer(Pan-cancer,PMID28119430) Gordian et al.2019-TGFbeta-EMTsignature(Non-small cell lung carcer,PMID30783512) Gotzmann et al.2006-Induction of hepatocellular EMT(Hepatocellular carcinoma,PMID16607286) Groeger et al.2012-Genes up-regulated in EMT based on a meta-analysis(Human cancer,PMID23251436) Grosse-Wilde et al.2015-EM expression signature and stemness(Breast Cancer,PMID26020648) Hennessy et al.2009-Tumorigenic signature defined using CD44(+)/CD24(-) breast tumor-initiating stem cell-like cells(Breast Cancer(metaplastic ),PMID19435916) Higashikawa et al.2008-Sponataneous and Snail-induced EMT revealed genes with EMT phenotype(Squamous cell carcinoma,PMID18329791) Hollern et al.2018-Predictive gene signatures that identify specific histological mouse mammary tumor subtypes(Pan-cancer,PMID29346386) Huang et al.2013-33-gene EMT Signature in Ovarian Cancer cohort(Ovarian cancer,PMID24201814) Huang et al.2015-Mesenchymal Signature genes(Ovarian cancer,PMID26061747) Hussey et al.2012-Establishment of a TGFbeta-Induced Post-Transcriptional EMT Gene Signature(NMuMG,PMID23285117) Iseri et al.2011-Multidrug resistant MCF-7 associated EMT(Breast Cancer,PMID21177063) Javaid et al.2015-26-gene EMT RNA signature(Breast Cancer,PMID25678598) Jordan et al.2013-EMT gene signature shared between epithelial stem cells developmentally entering EMT and Claudin-low breast cancer cells(Breast Cancer,PMID23716599) Joyce et al.2009-Caco cell line expressing Ha-RasV12(Caco-H) with stong EMT phenotype(Colorectal cancer,PMID19340593) Kandimalla et al.2019-EMT-associated prognostic gene-expression signature(Pan-cancer,PMID31069256) Kim et al.2015-EMT-related gene signatures in TNBC(Triple Negative Breast cancer,PMID26088755) Klarmann et al.2009-EMT signature in Invasive prostate cancer(prostate cancer ,PMID19221883) Koplev et al.2018-Pan-cancer EMT signature(Pan-cancer,PMID29293502) Lee at al.2017-Mesenchymal subtype gene signature for clinical application in gastric cancer(Gastric cancer,PMID29029513) Liang et al.2015-EMT-TFs, mesenchymal and Epithelial (Non-small cell lung carcer,PMID26181204) Liang et al.2018-Differentially expressed EMT genes in clear-cell rennal cell carcinoma (Kidney cancer,PMID29700419) Loboda et al.2011-The EMT signature was derived from a microarray dataset with 93 lung cancer cell lines(Lung cancer,PMID21251323) Mak et el.2016-A Patient-Derived, Pan-Cancer EMT Signature(Pan-cancer,PMID26420858) Marchini et al.2012-EMT by transforming growth factor (TGF)-beta pathway(Ovarian cancer,PMID22897840) Mathews et al.2010-Aggressive tumor cells displaying EMT profile(Prostate Cancer,PMID20929579) Mlcochova et al.2016-EMT-associated microRNA/mRNA signature in clear-cell renal cell carcinoma(Kidney cancer,PMID27549611) Moor et al.2015-BCL9/9L-dependent gene signature derived from independent mouse colorectal cancer(Colorectal cancer,PMID26844272) MsigDB v7.0-Molecular signatures database EMT hallmark gene set(Pan-cancer,PMID26771021) Pitts et al.2013-EMT signature was associated with sensitivity to PAK inhibitor PF-03758309(Colorectal cancer,PMID23543898) Puram et al.2017-Common identified partial EMT genes in head and neck cancers(Head and Neck Cancer,PMID29198524) Reka et al.2014-97-gene EMT-associated secretory phenotype(Lung adenocarcinoma,PMID24510113) Remsik et al.2018-EMT associated 10-molecule surface signature(Breast Cancer,PMID29462126) Rokavec et al.2017-Pan-cancer EMT-signature(Human cancer,PMID28680090) Roudi et al.2016-Lung adenocarcinoma spheroid cells derived signature(Lung adenocarcinoma,PMID27048287) Sandsmark et al.2017-Wnt and EMT combined signature in prostate cancer(Prostate cancer,PMID28030815) Schell et al.2016-Gene Expression Signature to Optimize Prediction of Colorectal Cancer Metastasis and Outcome(Colorectal cancer,PMID26446941) Schliekelman et al.2015-Aggressive hybrid protein signature(Lung adenocarcinoma,PMID25744723) Sethi et al.2011-Molecular signature of EMT in human prostate cancer bone metastasis(Prostate Cancer,PMID21139809) Shaul et al.2014-Mesenchymal-metabolic signature(High grade carcinomas,PMID25171410) Soo Min et al.2019-Network-based TGFbeta-induced EMT signature(human peritoneal mesothelial cells,PMID30728376) Soundararajan et al.2015-EMT-/stem-cell markers(Breast Cancer,PMID26123483) Stylianou et al.2019-Epithelial mesenchymal plasticity signature(Prostate cancer,PMID30194451) Tang et al.2015-EMT markers and inducers(Triple Negative Breast cancer,PMID26170011) Taube et al.2010-Core EMT signature(Breast Cancer,PMID20713713) Thompson et al.2020-EMT signature to immune checkpoint blockade in lung cancer(Breast Cancer,PMID31683225) Tso et al.2015-Referred as EMT inducers as molecular signatures of GSC(Glioblastoma,PMID26546412) Tuan et al.2014-Generic EMT signature (g=315)(Human cancer,PMID25214461) Tun et al.2010-EMT gene expression signature of ccRCC(Clear cell renal cell carcinoma,PMID20502531) Voon et al.2013-EMT-induced stemness and tumorigenicity(Gastric cancer,PMID23950932) Wang et al.2017-Comparative gene co-expression network analysis of EMT reveals lung cancer progression stages(Lung cancer,PMID29212455) Wang et al.2018-Compiled EMT markers to construct an unbiased EMT signature(Urothelial cancer ,PMID30158554) Warzecha et al.2010-ESRP-regulated splicing signature(Breast Cancer/Prostate cancer ,PMID20711167) Xiong et al.2017-Esophageal cancer EMT signature(Esophageal squamous cell carcinoma,PMID28591712) Yauch et al.2005-Gene expression signature of EMT genes deregulated in high risk HNSCC(Non-small cell lung carcer,PMID16361555) Zarkoob et al.2013-Genetic signature of EMT(Glioblastoma,PMID23734191) Zhu et al.2018-EMT in gastic cancer(Gastric cancer,PMID29957874)

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Query Cohort to explore EMT-Signature (EMTscore) based survival (Profgression-free survival and Overall survival)

Cohort of Interest	Adrenocortical carcinoma (ACC) Bladder urothelial carcinoma (BLCA) Breast invasive carcinoma (BRCA) Cervical and endocervical cancers (CESC) Cholangiocarcinoma (CHOL) Colon cancer (COAD) Lymphoid Neoplasm Diffuse Large B-cell Lymphoma (DLBC) Esophageal carcinoma (ESCA) Glioblastoma multiforme (GBM) Head and Neck squamous cell carcinoma (HNSC) Kidney Chromophobe (KICH) Kidney renal clear cell carcinoma (KIRC) Kidney renal papillary cell carcinoma (KIRP) Acute Myeloid Leukemia (LAML) Brain Lower Grade Glioma (LGG) Liver hepatocellular carcinoma (LIHC) Lung adenocarcinoma (LUAD) Lung squamous cell carcinoma (LUSC) Mesothelioma (MESO) Ovarian serous cystadenocarcinoma (OV) Pancreatic adenocarcinoma (PAAD) Pheochromocytoma and Paraganglioma (PCPG) Prostate adenocarcinoma (PRAD) Rectal adenocarcinoma (READ) Sarcoma (SARC) Skin Cutaneous Melanoma (SKCM) Stomach adenocarcinoma (STAD) Testicular Germ Cell Tumors (TGCT) Thyroid carcinoma (THCA) Thymoma (THYM) Uterine Corpus Endometrial Carcinoma (UCEC) Uterine Carcinosarcoma (UCS) Uveal Melanoma (UVM)

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